These are oral tablets that act directly on the kidneys. They inhibit the reabsorption of glucose from the blood circulating in the kidneys back into the blood circulating in the body, thereby reducing blood glucose levels. The excess glucose from the blood is then passed out of the urine. SGLT2i’s have a weight loss benefit, the have been proven to have significant protective effects on the kidneys and have no hypoglycaemic risk as they do not have any effect on insulin levels.